The Sarcomeric Human Cardiomyopathy Registry (ShaRe) has been set up to advance our understanding of Hypertrophic Cardiomyopathy (HCM) and Dilated Cardiomyopathy (DCM). These heritable heart diseases are caused by mutations in the protein genes of the sarcomere, the fundamental contractile unit of heart muscle. They are genetically passed on in families in an autosomal dominant pattern of inheritance. The prevalence of these diseases, taken together, is usually estimated at 1 in 500 individuals in the general population.

By contributing anonymized clinical and laboratory data from the patients and families under their care, these investigators are making this registry one of the largest and most detailed datasets of its kind in this disease area.

Funded by research grants from MyoKardia, Inc., SHaRe brings together a group of experienced, knowledgeable cardiologists and geneticists from the United States and Europe with a passion for helping people with genetic heart disease.

MyoKardia’s mission is to revolutionize the treatment of genetic cardiomyopathies and related heart diseases through  advances in sarcomere-related biochemistry and molecular biology.

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Meet the Team

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Share Your Story

Browse personal stories from patients & family members of those with HCM and DCM, and even share your own story!

Join Research Studies

Find out if you qualify for the newest cardiomyopathy clinical trials.

Question of the Month

What is the cause of Hypertrophic cardiomyopathy?
— Jane S., Boston, MA

A: Hypertrophic cardiomyopathy is a condition that is usually passed down through families (inherited). It is believed to be a result of several problems (defects) with the genes that control heart muscle growth.

To get some help with what type of question you might want to ask, check out our Guidelines

NOTE: SHaRe and do  not provide any medical advice.  We are an informational site only.  Always seek and follow the advice from your own physician or qualified health care provider on medical advice or treatment.   Learn more here.

Research Centers

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Preparing for Your Visit

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HCM & DCM Facts

We know it can be a challenge to traverse the world of inherited cardiomyopathy. Get the facts here:

Keep up with the newest HCM & DCM headlines and events.

International SHaRe Locations Around the World

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Number of people (patients & their family members) currently represented in the International SHaRe Registry:


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